Rhodium(II)‐Catalyzed Regioselective Carbenoid Insertion Reaction of Simple Indoles with <i>N</i>‐Sulfonyltriazoles: A Rapid Access to Tryptamine Vinylogues

Abstract

Abstract A synthetically useful 1,3‐insertion reaction of a rhodium‐carbenoid into the C( sp 2 )H bond of simple indole is disclosed, which produces structurally divergent 2‐indolylenamides in good to excellent yields and decent chemo‐ and regioselectivities. The obtained tryptamine vinylogues can be transformed into biologically important tryptamine derivatives or 3,3′‐biindoles with ease. magnified image