The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway

Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals

Maureen K. Bunger, Lisa D. Wilsbacher, Susan M. Moran et al. · Cell · 2000 · 1.6K citations · Full text

Life Sciences, Biochemistry, Physiology +13

Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock

Roman V. Kondratov, Anna A. Kondratova, Victoria Gorbacheva et al. · Genes & Development · 2006 · 1.2K citations · Full text

Education, Molecular Genetics, Physiology +17

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

Nian Huang, Yogarany Chelliah, Yongli Shan et al. · Science · 2012 · 358 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

L. Amanda Sadacca, Katja Lamia, Andrew S. deLemos et al. · Diabetologia · 2010 · 309 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

Jerry E. Chipuk, John C. Fisher, Christopher P. Dillon et al. · Proceedings of the National Academy of Sciences · 2008 · 244 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16