Antioxidant, antipyretic and choleretic activities of crude extract and active compound of Polygonum Bistorta (Linn.) in albino rats

Abstract

Objective: To evaluate the antioxidant, antipyretic and choleretic activities of crude extract of Polygonum Bistorta and active compound (tannic acid) in experimental animal models. Crude extract and active compound of Polygonum Bistorta was evaluated for antioxidant activity DPPH free radical scavenging activity, antipyretic yeast induced activity and choleretic activity of bile flow and bile solids. The results indicate that active principle had the better scavenging activity and showed a promising effect, choleretic activity of extract and active compound did not show any adverse effect on liver. Aqueous extract of Polygonum Bistorta (100 mg/kg) and tannic acid (25 mg/kg) showed reduced pyrexia activities. The present study shows that aqueous extract of Polygonum Bistorta (100 mg/kg) and tannic acid (25 mg/kg has a significant antioxidant, antipyretic and choleretic properties. Thus it may be concluded that tannic acid (25 mg/kg) were found more effective values towards control.