Development · 1969 · 46 citations · 17 references
Life SciencesCell BiologyDevelopmental BiologyCell DifferentiationOrganogenesisTissue DifferentiationEpidermal TissueEpithelial DifferentiationEpithelial MorphogenesisEpithelial TissueEpithelial-mesenchymal InteractionsExtracellular MatrixEpidermal Tissue MorphogenesisEpithelial-mesenchymal TransformationEpithelium-mesenchyme TransitionMesenchymal TissueMesenchyme FormationSalivary Gland EmbryologyThyroid Gland Development
ABSTRACT Epidermal organogenesis (thyroid gland, salivary gland, feather, hair, skin, thymus gland, tooth, etc.) generally follows a basic rule; epithelium exhibits well-documented interdependence with adjacent mesenchyme for a specific path of development (Grobstein, 1967, for review). Koch (1967) demonstrated in rodent embryos that isolates of incisor epithelial and mesenchymal tissue, separated by a millipore filter, continued to develop. When homotypic tissues were placed in juxtaposition to the filter, no evidence of continued differentiation was observed.
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