Biomarkers · 2015 · 106 citations · 34 references
Life SciencesNeurologyNeuroscienceEarly DetectionMolecular NeuroscienceNeurodegenerationBiomarkers Of NeurodegenerationMicrorna BiologyNeurodegenerative DiseasesNeurodegenerative DisordersParkinson DiseaseParkinsonian DisordersBiomarkers Of Parkinsonian DisordersCirculating Microrna DetectionCirculating MicrornasCirculating Rna BiomarkersMicrorna BiomarkersMicrorna ScreeningNovel Circulating BiomarkersParkinson Disease Biomarkers
CONTEXT: Sensitive, non-invasive biomarkers that facilitate Parkinson's disease (PD) detection and stage assignment are currently unavailable. OBJECTIVE: The objective of this study is to investigate the potential of circulating microRNAs (miRNAs) as novel biomarkers for PD. MATERIALS AND METHODS: Solexa sequencing technology and quantitative real-time PCR were applied to screen and verify altered serum miRNAs in PD patients. RESULTS: Serum miR-141, miR-214, miR-146b-5p, and miR-193a-3p were decreased significantly in PD patients compared with controls. Furthermore, the 4-miRNA panel enabled the differentiation of HY stage 1 and 2 PD patients from controls. DISCUSSION AND CONCLUSION: The four serum miRNAs may represent novel biomarkers for the early detection of PD.
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Xi Chen, Yi Ba, Lijia Ma et al. · Cell Research · 2008 · 4.6K citations
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Alexander Zimprich, Saskia Biskup, Petra Leitner et al. · Neuron · 2004 · 3.1K citations · Full text