Antidiabetic activity and modulation of antioxidant status by sansevieria roxburghiana rhizome in streptozotocin-induced diabetic rats.

Abstract

SUMMARY The present study evaluated antidiabetic activity of hydroalcoholic extract of Sansevieria roxburghiana rhizome (HASR) in streptozotocin-induced diabetic rats. Hyperglycemia was induced in rats by streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, diabetic rats received HASR orally at 50 and 100 mg/kg body weight daily for 15 days. Glibenclamide (0.5 mg/kg, orally) served as reference. Blood glucose levels were measured on every 5 th day during 15 days. Serum biochemical parameters viz. SGPT, SGOT, SALP, cholesterol, triglycerides, and total protein were estimated. Hepatic and renal lipid peroxidation, reduced glutathione (GSH) and catalase (CAT) were also assessed. HASR significantly (P<0.001) and dose dependently normalized blood glucose levels, serum biochemical parameters; decreased lipid peroxidation and recovered GSH and CAT as compared to those of STZ controls. Therefore, S. roxburghiana rhizome demonstrated remarkable antidiabetic activity in STZinduced diabetic rats. The potential antidiabetic action is plausibly due to its modulation of endogenous antioxidant status.