Journal of Lipid Research · 1971 · 175 citations · 10 references
Bioorganic ChemistryAldo-keto ReductaseMolecular BiologyChemical BiologyEnzymatic ModificationRedox BiologyBiosynthesisBioanalysisAldehyde Dehydrogenase3-Hydroxy-3-methylglutaryl CoenzymeBiochemistryC AnhydrideHmg Coa ReductaseCellular EnzymologyNatural SciencesHeme DegradationSubstrate Precursor Hmg-3-MetabolismMedicine
Two improvements are described for the assay of HMG CoA reductase. These are a simple synthesis of the substrate precursor HMG-3-(14)C anhydride and a double-label ((14)C and (3)H) method for determining the amount of mevalonate-3-(14)C that is formed from the substrate.
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