The -463G/A polymorphism in myeloperoxidase gene and cervical cancer.

Abstract

BACKGROUND: Cervical cancer is the leading cause of cancer-related death in women in developing countries. The -463 type G polymorphism of the MPO gene has been correlated with higher MPO expression and increased risk of various types of cancers. Our study was performed in order to evaluate the association between the -463G polymorphism and the prevalence of cervical cancer. MATERIALS AND METHODS: In our prospective study, 149 patients with cervical cancer and 126 patients without any malignancies were enrolled. RESULTS: No significant difference was found between genotype distributions in the cervical cancer patients and the control group. There was also no significant association of the genotype distributions with clinical prognostic factors. However, significantly lower A allele frequency of the -463 polymorphism of the MPO gene was found in our study group in comparison with that of the average Caucasian population. CONCLUSION: The -463 polymorphism of the MPO gene was not associated with susceptibility to cervical cancer.