High-Affinity Interaction of Tyrosine Kinase Inhibitors with the ABCG2 Multidrug Transporter

A multidrug resistance transporter from human MCF-7 breast cancer cells

L. Austin Doyle, Weidong Yang, Lynne V. Abruzzo et al. · Proceedings of the National Academy of Sciences · 1998 · 2.3K citations

Medicine, Oncology, Pharmacology +16

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

Sheng Zhou, John D. Schuetz, Kevin D. Bunting et al. · Nature Medicine · 2001 · 2.3K citations

Life Sciences, Cell Biology, Molecular Biology +7

Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor

Heikki Joensuu, Peter Roberts‎, Maarit Sarlomo‐Rikala et al. · New England Journal of Medicine · 2001 · 2.1K citations · Full text

Medicine, Cancer Biology, Oncology +17

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

Marc Maliepaard, George L. Scheffer, Ian F. Faneyte et al. · PubMed · 2001 · 1.1K citations

Medicine, Cancer Biology, Oncology +14

Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor

Michael C. Heinrich, Diana Griffith, Brian Druker et al. · Blood · 2000 · 1.1K citations

Life Sciences, Molecular Biology, Pharmacology +16