PubMed · 2004 · 24 citations · 6 references
MedicineEndocrinologyInternal MedicineEndocrine SurgeryHepatologyWomen's HealthEndocrine DiseaseEndocrine Metabolic DisordersLipid DisordersPancreatic DiseasesPancreatic DisordersPancreatic PathologyEndocrine Pancreatic InsufficiencyHyperlipidemic PancreatitisNecrotizing PancreatitisPancreatic Endocrine DisordersPancreatic Endocrine DysfunctionPancreatic Endocrine InsufficiencyPancreatic FailurePancreatitis Risk
CONTEXT: Acute pancreatitis is related to drugs in 1.4-2% of cases. Estrogens are an uncommon but well-known risk factor of pancreatitis in women and men with pre-existing hyperlipidemia. CASE REPORT: We report the case of a 37-year-old man with covert hypertriglyceridemia who developed a severe life-threatening pancreatitis strongly associated with estrogen therapy preparatory to sex change surgery, characterized by a massive triglyceride level, pancreatic insufficiency and multiple organ failure at the time of the diagnosis. Other causes of the disease were ruled out. CONCLUSIONS: To our knowledge, this is the first description of severe necrotizing estrogen-induced pancreatitis in a male. Baseline abnormal triglyceride levels should be checked by physicians before starting estrogen therapy in women and men.
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