A Study of the Kultschitzky (Argentaffin) Cell with the Electron-microscope, after Fixation by Osmium Tetroxide

Abstract

ABSTRACT 1. The Kultschitzky cells of the alimentary canal of man and the guinea-pig were studied with the light-microscope, buffered osmium tetroxide being used as fixative. 2. The Kultschitzky cells of the guinea-pig were shown by the electron-microscope to contain spheroidal granules having a maximum diameter of 0·3 μ. These granules are considerably darkened by fixation for only 4 hours in 1% osmium tetroxide solution. 3. The opinion that the granules of the Kultschitzky cell are only an artifact of formaldehyde fixation is denied.