2008 · 17 citations · 0 references
PharmacyPharmaceutical AnalysisPharmaceuticsBioavailabilityDosage Form DesignPharmaceutical FormulationDrug DispositionSpectroscopic Analysis Of PharmaceuticalsConcentrationQuality Control AnalysisRecovery StudiesUv-visible Quantitative Analysis
A simple, sensitive, sectrophotometric method in UV region has been developed for the determination of Letrozole is bulk and tablet dosage form. Standard solution of Letrozole shows maximum absorbance at240nm with apparent molar absorptive of 3.3016 × 10 4 l/mol/cm. Beers law was obeyed in the concentration range of 1 -10 µg /m.l with regression ,slope and intercept 0.9998,-0.016,0.1164 respectively. Result of the analysis was validated statically and by recovery studies. The results percentage recovery is100.63±0.4215 which shows that the method is free form interference of additives and impurities during the estimation drug in formulation. This shows the adoptability of the method for the routine quality control analysis of the drug in bulk and in formulation.