An assessment of the histomorphometric evidences of doxorubicin-induced testicular cytotoxicity in Wistar rats

Abstract

th week after DOX administration. The gross anatomical parameters assessed included the testicular weights and volumes while stereological parameters estimated include: diameter and cross-sectional area of the seminiferous tubules; number of profiles per unit area and numerical density of seminiferous tubules. The results showed that there was a general destruction along with degeneration of cells of the seminiferous epithelium following DOX administration. There was also a demonstratable progressive worsening of the testicular derangement with passage of time following DOX challenge. We conclude that DOX has a deleterious effect on the testis.