Anti-Tubercular Activity of Isatin Derivatives

Abstract

Tuberculosis (TB) remains among the world’s great public health challenges. Worldwide resurgence of TB is due to two major problems: the acquired immunodeficiency syndrome (AIDS) epidemic, which started in the mid-1980s, and the outbreak of multidrug resistant tuberculosis (MDR-TB). Thus, there is an urgent need for anti-TB drugs with improved properties such as: Enhanced activity against MDR strains, reduced toxicity, shortened duration of therapy, rapid mycobactericidal mechanism of action and the ability to penetrate host cells and exert antimycobacterial effects in the intracellular environment. Indoline-2,3-dione (isatin) derivatives are reported to show antitubercular activities, accordingly, isatin is a versatile lead molecule for designing of potential anti-tubercular agent. The current review outlines isatin derivatives with potential anti-tubercular activity.