Concepedia

Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity

Seyedeh Mahdieh Hashemi, Saeed Emami

Pharmaceutical and Biomedical Research · 2015 · 51 citations · 41 references

DOIFull text

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Concepts

Abstract

, also known as polyphenoloxidase (PPO), is a coppercontaining bifunctional enzyme with a molecular weight of approximately 60-70 kDa in mammals and is found exclusively in melanocytes (1,4). It catalyzes two distinct reactions of melanin synthesis (Fig.

References

41

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Screening for Tyrosinase Inhibitors among Extracts of Seashore Plants and Identification of Potent Inhibitors from<i>Garcinia subelliptica</i>

Toshiya Masuda, Daiki Yamashita, Yoshio Takeda et al. · Bioscience Biotechnology and Biochemistry · 2005 · 349 citations

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Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors

Ernest V. Curto, Cecil D. Kwong, H. Hermersdörfer et al. · Biochemical Pharmacology · 1999 · 321 citations

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Kojic acid–amino acid conjugates as tyrosinase inhibitors

Jin‐Mi Noh, Seon‐Yeong Kwak, Hyosuk Seo et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 142 citations · Full text

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Kojic acid and its manganese and zinc complexes as potential radioprotective agents

Saeed Emami, Seyed Jalal Hosseinimehr, Seyed Mohammad Taghdisi et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 122 citations

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