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MULTIPLEXED VIABILITY, CYTOTOXICITY AND APOPTOSIS ASSAYS FOR CELL-BASED SCREENING
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2006
Year
Unknown Venue
Combinatorial ChemistryBioorganic ChemistryCell DeathOrganic ChemistryChemistryChemical BiologyMultiplexed ViabilityMedicinal ChemistryCombinatorial Synthesis ChemistriesMolecular DiagnosticsRecent AdvancesSmall Molecule LibraryNew Chemical EntitiesBiochemistryNatural Product SynthesisCell BiologyNatural SciencesRational Drug DesignMedicineDrug DiscoveryHigh-throughput ScreeningDrug Analysis
Recent advances in combinatorial synthesis chemistries have led to both larger and more focused libraries of new chemical entities. The challenge continues to be testing these compounds for biological effects while maintaining cost economy. Although increasing throughput has helped efficiency, a number of factors shape the quality of the data derived from a screen. Ultimately, this quality dictates the probability of identifying active compounds worthy of further characterization.