Review on Preparation and Characterization of Liposomes with Application

Abstract

Liposomes are microscopic vesicles composed of a bilayer of phospholipids or any similar amphipathic lipids. They can encapsulate and effectively deliver both hydrophilic and lipophilic substances 2‐3 and may be used as a non‐toxic vehicle for insoluble drugs. Liposomes are composed of small vesicles of phospholipids encapsulating an aqueous space ranging from about 0.03 to 10 µm in diameter. The membrane of liposome is made of phospholipids, which have phosphoric acid sides to form the liposome players. Liposomes can be manufactured in different lipid compositions or by different method show variation in particle size, size distribution, surface electrical potential, no. of lamella, encapsulation efficacy, Surface modification showed g+reat advantage to produce Liposomes of different mechanisims, kinetic properties and biodistribution. Products in the market are Doxorubicin (Doxil, Myocet), Daunorubicin (Dauno Xome), Cytarabin (Depocyte), (lymphotmatos meningitis) and Amphotericine B (Ambisome), (fungal infection). An artificial microscopic vesicle consisting of an aqueous core enclosed in one or more phospholipid layers, used to convey vaccines, drugs, enzymes, or other substances to target cells or organs. Liposomes are nano size artificial vesicles of spherical shape.