Formulation and evaluation of Gastro retentive Multiparticulate Drug delivery system of Aceclofenac

Abstract

Gastroretentive dosage forms have potential for use as controlled-release drug delivery systems. Multiple unit systems avoid the 'all-or-none' gastric emptying nature of single unit systems. A controlled release system for aceclofenac designed to increase its residence time in the stomach without contact with the mucosa was achieved through the preparation of floating microparticles by the emulsification solvent-evaporation technique consisting of eudragit RS 100 as a polymer. The shape and surface morphology of prepared microsphere were characterized by optical and scanning electron microscopy. The micromeritic properties of microspheres were found to be much improved. In-vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method. Effects of polymer concentration, stirring rate during preparation and effect of temperature on size and drug release was evaluated. The prepared microspheres exhibited prolonged drug release (> 12h) and remained buoyant for > 12 h. The mean particle size increased and the drug release rate decreased at higher polymer concentration. No significant effect of the stirring rate during preparation on drug release was observed. As the temperature increased the release of drug was fast due to shell of the microspheres was very thin and some of the microspheres were broken. In-vitro studies demonstrated diffusion- controlled drug release from the microspheres.