RECENT ADVANCEMENT IN TRANSDERMAL DRUG DELIVERY SYSTEM

Abstract

Transdermal administration of drugs is an another way of administration that can significantly deliver larger molecules in potent quantities that overcome the problem with the oral administration such as poor bioavailability due to first pass metabolism and sometimes responsible for rapid blood level spikes (both high and low). Drugs that are given by transdermal route may enhance the potency as well as safety of drugs. Most oftenly the medicament containing device remains in contact with the body skin that is required to reduce both the size and frequency of doses required to achieve the plasma concentrations. There are various types of transdermal patches which are further modified to increase the potential of the drug delivery. New Transdermal Drug Delivery System (TDDS) Technologies now have been developed that is considered to be helpful in rate controlled delivery of drug that are difficult to administer. This review article emphasize most of the technologies involved in better permeation through skin into an effective Drug Delivery System.