Nootropic Activity of BacoMind, An Enriched Phytochemical Composition from Bacopa monnieri

Abstract

The objective of this study was to evaluate the nootropic activity of BacoMind TM , an enriched phytochemical composition from Bacopa monnieri , in different learning and memory paradigms viz ., elevated plus maze, passive shock avoidance test and object recognition test. BacoMind was administered for 7 days at the dose of 40, 60 and 80 mg/kg to mice in elevated plus maze and passive shock avoidance test and 27, 40 and 54 mg/kg to rats in object recognition test. Scopolamine (0.3 mg/kg) was used to induce amnesia and piracetam (100 mg/kg) served as reference standard. In elevated plus maze test, BacoMind TM significantly (p<0.01) increased the inflexion ratio in scopolamine treated mice. In passive shock avoidance test, BacoMind TM significantly (p<0.001) reduced the latency to reach the shock free zone and number of mistakes in 15 min in both normal as well as scopolamine treated mice. In object recognition test, BacoMind TM significantly (p<0.001) increased the discrimination index in both normal as well as scopolamine treated rats. Thus, the findings of the present study revealed the nootropic activity of BacoMind TM .