Concepedia

Screening of Stabilizers for LC–MS/MS Analysis of Clevidipine and its Primary Metabolite in Dog Whole Blood

Peng Cao, Li Gao, Ling Huang, Shouwei Zhao, Yang Hu, Lixia Qin, Lihui Qiu, Wenwen Zhu, Luqin Si, Jiangeng Huang

Bioanalysis · 2015 · 10 citations · 14 references

DOI

Abstract

The stabilizer cocktail was able to effectively suppress the activity of esterase in blood. The method was successfully applied to a PK study of clevidipine in beagle dogs.

References

14

Strategies in quantitative LC‐MS/MS analysis of unstable small molecules in biological matrices

Wenkui Li, Jie Zhang, Francis L. S. Tse · Biomedical Chromatography · 2010 · 141 citations

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Clevidipine Effectively and Rapidly Controls Blood Pressure Preoperatively in Cardiac Surgery Patients: The Results of the Randomized, Placebo-Controlled Efficacy Study of Clevidipine Assessing Its Preoperative Antihypertensive Effect in Cardiac Surgery-1

Jerrold H. Levy, Miguel Y. Mancao, Richard Gitter et al. · Anesthesia & Analgesia · 2007 · 110 citations

Determination of remifentanil in human blood by liquid-liquid extraction and capillary GC-HRMS-SIM using a deuterated internal standard

C M Grosse, Ian M. Davis, R. F. Arrendale et al. · Journal of Pharmaceutical and Biomedical Analysis · 1994 · 67 citations

, , +13

In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolised by esterases, in different animal species and man

Hans Ericsson, Bengt Tholander, C G Regårdh · European Journal of Pharmaceutical Sciences · 1999 · 66 citations

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Pharmacokinetics and Arteriovenous Differences in Clevidipine Concentration following a Short- and a Long-term Intravenous Infusion in Healthy Volunteers

Hans Ericsson, Ulf Bredberg, Ulf G. Eriksson et al. · Anesthesiology · 2000 · 52 citations · Full text