Safety Validation of Repeated Blood–Brain Barrier Disruption Using Focused Ultrasound

Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

Kullervo Hynynen, Nathan McDannold, Natalia Vykhodtseva et al. · Radiology · 2001 · 1.5K citations

Medicine, Biomedical Engineering, Radiology +17

Convection-enhanced delivery of macromolecules in the brain.

R. Hunt Bobo, Douglas W. Laske, Aytaç Akbaşak et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

Pharmacy, Neuroscience, Pharmaceutics +16

Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

Kullervo Hynynen, Nathan McDannold, Nickolai Sheikov et al. · NeuroImage · 2004 · 686 citations

Engineering, Biomedical Engineering, Neuroscience +12

Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

Nathan McDannold, Costas Arvanitis, Natalia Vykhodtseva et al. · Cancer Research · 2012 · 595 citations · Full text

Pharmacy, Neurobiology, Neuroscience +17

Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium

Nickolai Sheikov, Nathan McDannold, Shipra Sharma et al. · Ultrasound in Medicine & Biology · 2008 · 495 citations · Full text

Veterinary Medicine, Bioengineering, Neuroscience +17