A versatile approach to flavones via a one-pot Pd(<scp>ii</scp>)-catalyzed dehydrogenation/oxidative boron-Heck coupling sequence of chromanones

Abstract

A variety of flavones were expediently synthesized from readily accessible chromanones via a one-pot sequence involving Pd(II)-catalyzed dehydrogenation and oxidative boron-Heck coupling with arylboronic acid pinacol esters. In particular, the use of arylboronic acid pinacol esters was found to significantly improve the yield of the reaction.