Concepedia

The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma

Hai-Feng Zhang, Ye Chen, Chengsheng Wu, Zhi-Yong Wu, David J. Tweardy, Abdulraheem Alshareef, Lian-Di Liao, Yu-Jie Xue, Jian-Yi Wu, Bo Chen,

Clinical Cancer Research · 2015 · 53 citations · 42 references

DOIFull text

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Abstract

STAT3β suppresses chemoresistance and cancer stemness by blocking the transcriptional activity of STAT3α. The paradoxical increase in pSTAT3α(Y705) induced by STAT3β carries important implications as to how the biologic and prognostic significance of STAT3 in cancers should be interpreted.

References

42

Global cancer statistics

Ahmedin Jemal, Freddie Bray · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Stat3 as an Oncogene

Jacqueline Bromberg, Melissa H Wrzeszczynska, Geeta Devgan et al. · Cell · 1999 · 2.8K citations · Full text

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Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

James Turkson, Tammy Bowman, Roy Garcia et al. · Molecular and Cellular Biology · 1998 · 657 citations · Full text

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

Tammy Bowman, Martin A. Broome, Dominic Sinibaldi et al. · Proceedings of the National Academy of Sciences · 2001 · 491 citations · Full text

Role of Stat3 in Regulating p53 Expression and Function

Guilian Niu, Kenneth L. Wright, Yihong Ma et al. · Molecular and Cellular Biology · 2005 · 395 citations · Full text

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