Concepedia

Duloxetine (Cymbalta™), a dual inhibitor of serotonin and norepinephrine reuptake

F.P. Bymaster, E. E. Beedle, Jeremy Findlay, P. T. Gallagher, Joseph H. Krushinski, S.N. Mitchell, David W. Robertson, David C. Thompson, Louise Wallace, David T. Wong

Bioorganic & Medicinal Chemistry Letters · 2003 · 123 citations · 4 references

Open access

Concepts

MedicinePharmacologyPharmacotherapyNeuropharmacologyPsychiatric PharmacotherapyPsychopharmacologyAntidepressant PharmacologyAntidepressant PharmacotherapyAntidepressant TherapyPsychostimulant PharmacologySerotonergic PharmacologyStimulant PharmacotherapyDuloxetine TherapyNorepinephrine Reuptake InhibitionSelective Serotonin Reuptake Inhibitor TreatmentSelective Serotonin-norepinephrine Reuptake Inhibitor TherapySerotonin-norepinephrine Reuptake Inhibitor Treatment

References

4

Duloxetine, 60 mg Once Daily, for Major Depressive Disorder

Michael J. Detke, Yili Lu, D. Goldstein et al. · The Journal of Clinical Psychiatry · 2002 · 385 citations

Medicine, Pharmacotherapy, Psychiatry +17

LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake

David T. Wong, Frank P. Bymaster, Douglas A. Mayle et al. · Neuropsychopharmacology · 1993 · 221 citations · Full text

Medicine, Neuroscience, Pharmacology +11

Asymmetric synthesis and absolute stereochemistry of LY248686

Jack B. Deeter, Jeff Frazier, G. S. STATEN et al. · Tetrahedron Letters · 1990 · 82 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

An asymmetric synthesis of duloxetine hydrochloride, a mixed uptake inhibitor of serotonin and norepinephrine, and its C‐14 labeled isotopomers

William J. Wheeler, Fengjiun Kuo · Journal of Labelled Compounds and Radiopharmaceuticals · 1995 · 22 citations

Medicine, Medicinal Chemistry, Pharmacology +17