Interleukin-35 upregulates OPG and inhibits RANKL in mice with collagen-induced arthritis and fibroblast-like synoviocytes

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

Young‐Yun Kong, Hiroki Yoshida, Ildiko Sarosi et al. · Nature · 1999 · 3.4K citations

Medicine, Cell Biology, Immunology +14

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

Lauren W. Collison, Creg J. Workman, Timothy Kuo et al. · Nature · 2007 · 2K citations

Life Sciences, Cell Biology, Immunology +12

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Young‐Yun Kong, Ulrich Feige, Iidiko Sarosi et al. · Nature · 1999 · 1.9K citations

Medicine, Immunology, Pathobiology +17

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Kojiro Sato, Ayako Suematsu, Kazuo Okamoto et al. · The Journal of Experimental Medicine · 2006 · 1.5K citations · Full text

Life Sciences, Cell Biology, Immunology +17

IL-35-mediated induction of a potent regulatory T cell population

Lauren W. Collison, Vandana Chaturvedi, Abigail Henderson et al. · Nature Immunology · 2010 · 852 citations

Life Sciences, Cell Biology, Immunology +14