Concepedia

The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism

Pengxu Qian, Xi He, Ariel Paulson, Zhenrui Li, Tao Fang, John M. Perry, Fengli Guo, Meng Zhao, Lei Zhi, Aparna Venkatraman,

Cell stem cell · 2015 · 208 citations · 34 references

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34

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Anne Wilson, Elisa Laurenti, Gabriela Oser et al. · Cell · 2008 · 1.9K citations · Full text

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mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

John T. Cunningham, Joseph T. Rodgers, Daniel H. Arlow et al. · Nature · 2007 · 1.5K citations

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The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Tugba Simsek, Fatih Kocabaş, Junke Zheng et al. · Cell stem cell · 2010 · 1.1K citations · Full text

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A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

Yoon-Young Jang, Saul J. Sharkis · Blood · 2007 · 878 citations · Full text

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mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

Masahiro Morita, Simon‐Pierre Gravel, Valérie Chénard et al. · Cell Metabolism · 2013 · 838 citations · Full text

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