Concepedia

Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration

Lindsay E. Calderon, Shu Liu, Nova Arnold, Breakall Bethany, Joseph Rollins, Margaret W. Ndinguri

PLoS ONE · 2015 · 25 citations · 47 references

DOIFull text

Open access

Abstract

The present study indicates that nicotine-induced migration is mediated by MMP-9 production in an iPLA2β dependent manner. Our data suggests that BEL is a possible chemotherapeutic agent as it was found to reduce both nicotine-induced breast cancer tumor growth and lung metastasis.

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