The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)

Profound block in thymocyte development in mice lacking p56lck

Thierry Jo Molina, Kenji Kishihara, David P. Siderovski et al. · Nature · 1992 · 961 citations

Knockout Mouse, Signal Transduction, Cell Regulation +8

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

Steven D. Levin, Sarah Anderson, Katherine A. Forbush et al. · The EMBO Journal · 1993 · 301 citations · Full text

Signal Transduction, Cell Regulation, Medicine +8

New Applications of Polyfunctional Organometallic Compounds in Organic Synthesis

Andreas Boudier, Lars O. Bromm, Matthias Lotz et al. · Angewandte Chemie International Edition · 2000 · 292 citations

Chemical Engineering, Engineering, Alkene Metathesis +9

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

Xiaotian Zhu, Joseph L. Kim, John Newcomb et al. · Structure · 1999 · 255 citations · Full text

Signal Transduction, Receptor Tyrosine Kinase, Molecular Biology +8

Stannylation reaction and cross-couplings in pyrimidines

Amera J. Majeed, Øyvind Antonsen, Tore Benneche et al. · Tetrahedron · 1989 · 86 citations

Combinatorial Chemistry, Cross-coupling Reaction, Stannylation Reaction +3