Antibiotics and chemotherapy/Antibiotica et chemotherapia · 2015 · 37 citations · 0 references
Life SciencesImmunologyMicrobiologyImmunology Of Infectious DiseasesInnate ImmunityMonoclonal AntibodiesBacterial ImmunologyComplement SystemImmunopathology Of Infectious DiseasesInflammation In Infectious DiseasePhagocyte BiologyAntibody-mediated Bacterial ProtectionAntibody-mediated Immunity To BacteriaBacterial AntibodiesBacterial Lipopolysaccharide RecognitionComplement In ImmunityLipopolysaccharide-mediated Pathogenesis
Mouse monoclonal antibodies that react with O-side chain specific, O-side chain cross-reactive, and core P. aeruginosa lipopolysaccharide determinants have been isolated. The monoclonals directed at O-side chain determinants are generally opsonophagocytic with human neutrophils and human complement. They also protect mice from intraperitoneal and intravenous challenge and protect in the burned rat model of infection.