Convenient synthesis of novel 4-substitutedamino-5-trifluoromethyl–2,7-disubstituted pyrido[2,3-d] pyrimidines and their antibacterial activity

Syntheses and antifolate activity of 5-methyl-5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid

James R. Piper, G. S. MCCALEB, Jane Montgomery et al. · Journal of Medicinal Chemistry · 1986 · 105 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +6

Studies on Condensed Pyrimidine Systems. XIX. A New Synthesis of Pyrido [2,3-d] pyrimidines. The Condensation of 1,3-Diketones and 3-Ketoaldehydes with 4-Aminopyrimidines

Roland K. Robins, George H. Hitchings · Journal of the American Chemical Society · 1958 · 74 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Reaction of Anthranilonitrile and N-Methylanthranilonitrile with Phenyl Isocyanate and Phenyl Isothiocyanate¹

Edward C. Taylor, R. V. Ravindranathan · The Journal of Organic Chemistry · 1962 · 61 citations

Natural Sciences, Chemistry, Mass Spectrometric Analysis +4

Synthesis and Biological Evaluation of 2,4-Diamino-6-(arylaminomethyl)pyrido[2,3-<i>d</i>]pyrimidines as Inhibitors of <i>Pneumocystis </i><i>c</i><i>arinii </i>and <i>Toxoplasma </i><i>g</i><i>ondii </i>Dihydrofolate Reductase and as Antiopportunistic Infection and Antitumor Agents

Aleem Gangjee, Ona O. Adair, Sherry F. Queener · Journal of Medicinal Chemistry · 2003 · 58 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Reactions of 5-(p-Anisyl)-2-methyl-7-(p-tolyl)-4H-pyrido[2,3-d][1,3]oxazin-4-one

Hassan M. F. Madkour, Hassan M. F. Madkour, Mounir A. I. Salem et al. · Heterocycles · 1994 · 36 citations · Full text

Natural Sciences, Chemistry, Organic Chemistry +4