Concepedia

First dual M3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives

Laurent Provins, B. Christophe, Pierre Danhaive, Jacques Dulieu, Véronique Durieu, Michel Gillard, Florence Lebon, Sébastien Lengelé, Luc Quéré, BerendJan van Keulen

Bioorganic & Medicinal Chemistry Letters · 2006 · 39 citations · 8 references

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References

8

Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in Vitro

Armin Hatzelmann, Christian Schudt · Journal of Pharmacology and Experimental Therapeutics · 2001 · 398 citations

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Immobilized-artificial-membrane chromatography: measurements of membrane partition coefficient and predicting drug membrane permeability

Shaowei Ong, Hanlan Liu, Charles Pidgeon · Journal of Chromatography A · 1996 · 265 citations

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In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor

Daniela S. Bundschuh, Manfrid Eltze, Johannes Barsig et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 239 citations

, , +16

Design and Synthesis of a Series of Non-Peptide High-Affinity Human Corticotropin-Releasing Factor<sub>1</sub> Receptor Antagonists

Chen Chen, Raymond Dagnino, Errol B. De Souza et al. · Journal of Medicinal Chemistry · 1996 · 137 citations · Full text

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Airway inflammation in chronic obstructive pulmonary disease

E. Rand Sutherland, Richard J. Martin · Journal of Allergy and Clinical Immunology · 2003 · 109 citations

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