PubMed · 2004 · 19 citations · 14 references
MedicineSurgeryEmergency SurgeryGastroenterologyGeneral SurgeryAbdominal SurgeryFistula ManagementGastrointestinal PerforationPostoperative ComplicationsPostoperative Gastrointestinal ComplicationsSurgical ComplicationsConservative Surgical TreatmentEmergency Gastrointestinal SurgeryEnterocutaneous Fistula ClosureGastrointestinal Fistula ManagementOperative TreatmentPatient Demographic VariablesPostoperative Fistula ComplicationsPostoperative Fistula Formation
OBJECTIVE: To identify the causes of postoperative enterocutaneous fistulas and to evaluate the results of conservative and operative treatment including the effectiveness of octreotide in the management of these fistulas. DESIGN: A descriptive study. PLACE AND DURATION OF STUDY: Department of Surgery, Liaquat University of Medical and Health Sciences, Jamshoro / Hyderabad between January 1997 and December 2001. SUBJECTS AND METHODS: Forty patients with postoperative fistula were studied. Demographic variables, causes and management outcome was observed and recorded. RESULTS: There were 25 males and 15 females with 50% of the patients being in age group of 21-30 years. Emergency surgery for typhoid perforation(45%) and intestinal tuberculosis (30%) were the commonest causes. Ileum and jejunum were the commonest sites of fistulation found in 85% cases. Twenty-one patients were started on conservative treatment with spontaneous closure occurring in 15 (71.4%) patients. Nineteen patients were operated within three days of admission due to generalized peritonitis (73.7%) and local intra-abdominal collections (26.3%). Wound infection was the commonest complication in the operative group. The mortality rate in this series was 7.5%. All the deaths occurred following surgery. CONCLUSION: Postoperative enterocutaneous fistula has a high morbidity and a significant mortality. Sepsis in the peritoneal cavity is the major cause of mortality. Conservative treatment has a good outcome for these fistulas. The use of octreotide is highly recommended as it definitely converts high output fistulas to low output fistulas.
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Principles that Govern the Folding of Protein Chains
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Klaus Düring, Petra Porsch, Andreas Mahn et al. · FEBS Letters · 1999 · 288 citations · Full text