Glomerulonephritis with - and 1C-globulin deposits induced in rats by mercuric chloride.

Abstract

Repeated subcutaneous injections of 0.15 or 0.25 mg/100 g of body weight of HgCl(2) may induce a membranous glomerulonephritis in rats. This glomerulonephritis with subepithelial deposits is similar, by electron microscopy and immunohistochemistry, to experimental chronic glomerulonephritis caused by immune complexes and to the human membranous glomerulonephritis.