Reactivity of 2-acylaminoacrylates with ketene diethyl acetal; [2 + 2] cycloadditions vs. tandem condensationsElectronic supplementary information (ESI) available: general procedures. See http://www.rsc.org/suppdata/cc/b3/b302000b/

Abstract

The reactivity of 2-acylaminoacrylates with ketene diethyl acetal can be modulated by means of thermal conditions to yield cyclobutanes for the preparation of protected beta-hydroxycyclobutane-alpha-amino acids, or catalytic conditions that yield cyclohexanes by tandem condensations to obtain interesting building blocks that are alternatives to Danishefsky's diene.