Phosphorus, sulfur, and silicon and the related elements · 2006 · 14 citations · 35 references
Natural SciencesChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryAntifungal AgentsHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsHeterocyclic Medicinal ChemistryNew Antifungal AgentsThiadiazole ChemistryThiazole ChemistryThiazole Synthesis
Abstract Different new 1,3,4-thiadiazolopyridine derivatives (6, 8, 20, 28, and 42) were synthesized from 5-cyanomethyl-1,3-4-thiadiazole (1) and activated nitriles. Also, spiro indolono-thiadiazolopyridine (12) was obtained from the reaction of (1) with 2-(2-oxoindolin-3-ylidene)malononitrile (10). Other heterocyclic derivatives at position-5 in the thiadiazole ring were obtained for possible use as antimicrobial agents. Keywords: 1,3,4-Thiadiazolesactived nitrilesthiadiazolopyridinepyridinefuro[2,3-b]indolepyridazine
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