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Efficient Synthesis of Novel γ-Substituted γ-Butenolides by Lewis Acid Catalyzed Addition of Metal Enolates of Active Methylene Compounds to Mucohalic Acids
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Citations
33
References
2005
Year
Asymmetric CatalysisChemical EngineeringNovel OrganocatalystsEngineeringIndium AcetateActive Methylene CompoundsOrganic ChemistryOrganometallic CatalysisCatalysisEfficient SynthesisChemistryMucobromic AcidNovel γ-Substituted γ-ButenolidesSynthetic ChemistryEnantioselective SynthesisCatalytic Synthesis
Lewis acid catalyzed addition of active methylene compounds to mucochloric acid (1) and mucobromic acid (2) affording Knoevenagel aldol adducts, gamma-substituted gamma-butenolides, has been explored. Catalytic efficiencies of various Lewis acids have been compared. Indium acetate (0.25-5 mol %) was found to be the most efficient catalyst.
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