Irisin relaxes mouse mesenteric arteries through endothelium-dependent and endothelium-independent mechanisms

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Boström, Jun Wu, Mark P. Jedrychowski et al. · Nature · 2012 · 4.7K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

Yuan Zhang, Rui Li, Yan Meng et al. · Diabetes · 2013 · 729 citations · Full text

Life Sciences, Biochemistry, Physiology +16

Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome

Kyung‐Hee Park, Lesya Zaichenko, Mary Brinkoetter et al. · The Journal of Clinical Endocrinology & Metabolism · 2013 · 511 citations · Full text

Medicine, Endocrinology, Physiology +13

α1Adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle

Chide Han, Peter W. Abel, Kenneth P. Minneman · Nature · 1987 · 481 citations

Life Sciences, Cell Biology, Physiology +16

Lower circulating irisin is associated with type 2 diabetes mellitus

Jianjun Liu, Melvin D.S. Wong, Wan Ching Toy et al. · Journal of Diabetes and its Complications · 2013 · 451 citations

Medicine, Endocrinology, Internal Medicine +4