Retinyl palmitate and ascorbic acid inhibit pulmonary neoplasms in mice exposed to fiberglass dust

Abstract

Abstract The influence of retinyl palmitate and ascorbic acid on the susceptibility of respiratory tract epithelium to the metaplastogenic, hyperplastogenic and tumorigenic effects of a 30‐day exposure to fiberglass dust was tested in 60 male A‐strain mice. Administration of retinyl palmitate or ascorbic acid, or both, significantly inhibited the development of metaplastic, hyperplastic and neoplastic lesions in these mice.