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Reactions between Weinreb Amides and 2-Magnesiated Oxazoles: A Simple and Efficient Preparation of 2-Acyl Oxazoles
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Citations
14
References
2007
Year
Weinreb AmidesDerivative (Chemistry)MedicineI-prmgcl SmoothlyOrganic ChemistryChemistryHeterocycle Chemistry5-Aryl OxazolesPharmacologySynthesis Method2-Acyl OxazolesSynthetic ChemistryReagentDrug Discovery2-Magnesiated Oxazoles2-Acyl Oxazole Products
Treatment of oxazole or 5-aryl oxazoles with i-PrMgCl smoothly generates the corresponding 2-Grignard reagents, which react with Weinreb amides to provide exclusively 2-acyl oxazole products.
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