Concepedia

Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity

Richard L. Elliott, Kimberly O. Cameron, Janice E. Chin, Jeremy A. Bartlett, Elena Beretta, Yue Chen, Paul Da Silva Jardine, Jeffrey S. Dubins, Melissa L. Gillaspy, Diane M. Hargrove,

Bioorganic & Medicinal Chemistry Letters · 2010 · 30 citations · 15 references

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Concepts

References

15

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction.

Rodger A. Liddle, Ira D. Goldfine, Matthew S. Rosen et al. · Journal of Clinical Investigation · 1985 · 750 citations · Full text

, , +15

Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin.

B. Evans, Mark G. Bock, Kenneth E. Rittle et al. · Proceedings of the National Academy of Sciences · 1986 · 328 citations · Full text

, , +16

Utility of Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS) for Initiation and Maintenance of Drug Supersaturation in the GI Milieu

William Curatolo, James Nightingale, Scott M. Herbig · Pharmaceutical Research · 2009 · 300 citations

, , +14

Dissolution Rate Enhancement by in Situ Micronization of Poorly Water-Soluble Drugs

Norbert Rasenack, Bernd W. Müller · Pharmaceutical Research · 2002 · 261 citations

, , +16