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Mechanisms of O2 Sensing in the Carotid Body in Comparison With Other O2-Sensing Cells
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1995
Year
Lipid PeroxidationRedox BiologyCellular PhysiologyOxidative StressCarotid BodyCell SignalingOther O2-sensing CellsMolecular PhysiologyBiochemistryVascular BiologyReactive Oxygen SpecieNervous SystemCell BiologySignal TransductionPhysiologySignal CascadeO2 Sensor ProteinMetabolismMedicineO2 Sensing
An NAD(P)H oxidase-generating H2O2 dependent on PO2 is proposed as an O2 sensor protein in type I cells of the carotid body, regulating potassium channel open probability as well as tyrosine hydroxylase gene expression. The proposed signal cascade also is important in other O2-sensing cells.