An Efficient Base-Free <i>N-</i>Arylation of Imidazoles and Amines with Arylboronic Acids Using Copper-Exchanged Fluorapatite

Abstract

N-Arylation of imidazoles and amines with arylboronic acids was accomplished with copper-exchanged fluorapatite (CuFAP) in methanol at room temperature. The products N-arylimidazoles and N-arylamines were isolated in good to excellent yields. A variety of arylboronic acids were converted to the corresponding N-arylimidazoles and N-arylamines, demonstrating the versatility of the reaction.