Chemical Communications · 1997 · 65 citations · 13 references
Natural SciencesChemistryCatalysisCatalytic MaterialsCatalytic MechanismsConformational AnalysisHeterocyclic ChemistryMacrocycle SynthesisSupported CatalystsCatalytic Reaction MechanismsMacrocycle CatalysisMacrocycle Conformation AnalysisMetathesis CatalysisRate DependenceRing-closing Metathesis
Grubbs’ ruthenium metathesis catalyst 1 was used to investigate the catalytic cyclisation/cleavage of tetrapeptide-derived macrocycles from a solid support; the rate dependence on substrate conformation has been studied.
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Prediction of protein conformation
Peter Y. Chou, Gerald D. Fasman · Biochemistry · 1974 · 3.3K citations
Synthesis of epothilones A and B in solid and solution phase
K. C. Nicolaou, Nicolas Winssinger, Joaquı́n Pastor et al. · Nature · 1997 · 399 citations