Bootstrap Analysis of Gene Networks Based on Bayesian Networks and Nonparametric Regression

Abstract

The development of the microarray technology provides us a huge amount of gene expression profiles. The estimation of a gene network has received considerable attention in the field of bioinformatics and several methodologies have been proposed such as the Boolean network [1], the Bayesian network [3, 4, 5] and so on. In this paper, we propose the method for measuring the reliability of the estimated gene network by using the bootstrap method [2].