In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for −174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

Daniel Fishman, Gary Faulds, Rachel Jeffery et al. · Journal of Clinical Investigation · 1998 · 2.2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

Jack Gauldie, Gerard Cox, Heinz Baumann et al. · Journal of Clinical Investigation · 1998 · 1.5K citations · Full text

Veterinary Medicine, Immunology, Pathology +17

Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly

Tamara B. Harris, Luigi Ferrucci, Russell P. Tracy et al. · The American Journal of Medicine · 1999 · 1.5K citations

Veterinary Medicine, Geriatric Medicine, Immunology +11

Serum IL‐6 Level and the Development of Disability in Older Persons

Luigi Ferrucci, Tamara B. Harris, Jack M. Guralnik et al. · Journal of the American Geriatrics Society · 1999 · 806 citations

Education, Geriatric Medicine, Immunology +17

Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation

Catherine Terry, Valérie Loukaci, Fiona R. Green · Journal of Biological Chemistry · 2000 · 800 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16