Autonomic Nervous System Activity During Bladder Filling Assessed by Heart Rate Variability Analysis in Women With Idiopathic Overactive Bladder Syndrome or Stress Urinary Incontinence

Abstract

No AccessJournal of UrologyAdult urology1 Dec 2007Autonomic Nervous System Activity During Bladder Filling Assessed by Heart Rate Variability Analysis in Women With Idiopathic Overactive Bladder Syndrome or Stress Urinary Incontinenceis accompanied byIncreased α1-Adrenergic Activity in the Rat Bladder by Depletion of Ovarian Hormones Katelyne Hubeaux, Xavier Deffieux, Samer Sheikh Ismael, Patrick Raibaut, and Gérard Amarenco Katelyne HubeauxKatelyne Hubeaux Université Pierre et Marie Curie-Paris 6, Faculté de Médecine, Unité Mixte de Recherche, Paris, France L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France L’Institut National de la Santé et de la Recherche Médicale (INSERM Unit 731), Paris, France More articles by this author , Xavier DeffieuxXavier Deffieux Université Pierre et Marie Curie-Paris 6, Faculté de Médecine, Unité Mixte de Recherche, Paris, France L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France L’Institut National de la Santé et de la Recherche Médicale (INSERM Unit 731), Paris, France More articles by this author , Samer Sheikh IsmaelSamer Sheikh Ismael L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France More articles by this author , Patrick RaibautPatrick Raibaut L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France More articles by this author , and Gérard AmarencoGérard Amarenco Université Pierre et Marie Curie-Paris 6, Faculté de Médecine, Unité Mixte de Recherche, Paris, France L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France L’Institut National de la Santé et de la Recherche Médicale (INSERM Unit 731), Paris, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.08.036AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Idiopathic overactive bladder syndrome is a common disorder, especially in women. Of various pathophysiological factors several studies suggest a specific dysfunction of the autonomic nervous system. To verify this hypothesis we compared heart rate variability parameters, which provide an analysis of autonomic function, in women with idiopathic overactive bladder syndrome to those in a reference population of women with stress urinary incontinence. Materials and Methods: Diseases and medications that can perturb the autonomic nervous system were excluded. We included 7 women with pure stress urinary incontinence and 3 with isolated overactive bladder syndrome. Continuous echocardiogram recording was performed with the bladder emptied and during artificial bladder filling. High frequency variations of instantaneous heart rate represent parasympathetic activity, low frequency variations represent sympathetic activity and the low-to-high frequency ratio represents the autonomic balance. Results: Heart rate variability parameters did not change significantly during bladder filling in women with stress urinary incontinence. In contrast, sympathetic tone in women with overactive bladder syndrome (low frequency) increased significantly at the end of bladder filling (p = 0.001), in parallel with a decrease in parasympathetic activity (high frequency) and a significant increase in the low-to-high frequency ratio (each p <0.001). Parasympathetic activity with the bladder emptied was significantly higher in the overactive bladder syndrome group (p = 0.017). Conclusions: This preliminary study demonstrates the predominance of parasympathetic activity with the bladder emptied and a preponderance of sympathetic activity at the end of bladder filling in women with overactive bladder syndrome. These results suggest dysfunction in the autonomic balance, as implied in idiopathic overactive bladder syndrome. 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Link, Google Scholar © 2007 by American Urological AssociationFiguresReferencesRelatedDetailsCited byHuang A, Grady D, Mendes W, Hernandez C, Schembri M and Subak L (2019) A Randomized Controlled Trial of Device Guided, Slow-Paced Respiration in Women with Overactive Bladder SyndromeJournal of Urology, VOL. 202, NO. 4, (787-794), Online publication date: 1-Oct-2019.Griebling T (2013) Re: Inhibitory Control Task is Decreased in Vascular Incontinence PatientsJournal of Urology, VOL. 191, NO. 3, (740-742), Online publication date: 1-Mar-2014.Palmer M, Hardin S, Behrend C, Collins S, Madigan C and Carlson J (2009) Urinary Incontinence and Overactive Bladder in Patients With Heart FailureJournal of Urology, VOL. 182, NO. 1, (196-202), Online publication date: 1-Jul-2009.Related articlesJournal of Urology17 Oct 2007Increased α1-Adrenergic Activity in the Rat Bladder by Depletion of Ovarian Hormones Volume 178Issue 6December 2007Page: 2483-2487 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordsbladderurinary incontinenceheart rateoveractiveautonomic nervous systemurinary bladderMetricsAuthor Information Katelyne Hubeaux Université Pierre et Marie Curie-Paris 6, Faculté de Médecine, Unité Mixte de Recherche, Paris, France L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France L’Institut National de la Santé et de la Recherche Médicale (INSERM Unit 731), Paris, France More articles by this author Xavier Deffieux Université Pierre et Marie Curie-Paris 6, Faculté de Médecine, Unité Mixte de Recherche, Paris, France L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France L’Institut National de la Santé et de la Recherche Médicale (INSERM Unit 731), Paris, France More articles by this author Samer Sheikh Ismael L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France More articles by this author Patrick Raibaut L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France More articles by this author Gérard Amarenco Université Pierre et Marie Curie-Paris 6, Faculté de Médecine, Unité Mixte de Recherche, Paris, France L’Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Universitaire Est, Hôpital Rothschild, Service de Rééducation Neurologique et d’Explorations Périnéales, Paris, France L’Institut National de la Santé et de la Recherche Médicale (INSERM Unit 731), Paris, France More articles by this author Expand All Advertisement PDF downloadLoading ...