Sexual Dysfunction in Male Schizophrenia: Influence of Antipsychotic Drugs, Prolactin and Polymorphisms of the Dopamine D2 Receptor Genes

Abstract

This is the first evidence indicating that antipsychotic drug treatment in men is associated with a variant in the DRD2 gene in which the -141C Del allele might be a protective factor. While this may, in part, be mediated by effects on prolactin, other factors are likely to contribute to the greater sexual dysfunction in patients receiving typical antipsychotics.