Airway Lipoxin A ₄ Generation and Lipoxin A ₄ Receptor Expression Are Decreased in Severe Asthma

Abstract

Mechanisms underlying pathological airway responses in severe asthma include lipoxin underproduction with decreased expression of lipoxin biosynthetic enzymes and receptors. Together, these results indicate that severe asthma is characterized, in part, by defective lipoxin counterregulatory signaling circuits.