Concepedia

A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis

Xin Yin, Jadwiga Truty, Roger Lawrence, Scott C. Johns, R. Sathish Srinivasan, Tracy M. Handel, Mark M. Fuster

Molecular Cancer · 2010 · 33 citations · 44 references

DOIFull text

Open access

Abstract

This work demonstrates the genetic importance of host lymphatic heparan sulfate in mediating chemokine dependent tumor-cell traffic in the lymphatic microenvironment. The impact on chemokine dependent lymphatic metastasis may guide novel therapeutic strategies.

References

44

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

, , +12

Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

Yaz Y. Kisanuki, Robert E. Hammer, Jun‐ichi Miyazaki et al. · Developmental Biology · 2001 · 1.2K citations

, , +10

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

Nicholas W. Gale, Gavin Thurston, Sean F. Hackett et al. · Developmental Cell · 2002 · 1K citations · Full text

, , +10

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes

Michael D. Gunn, Kirsten Tangemann, Carmen Tam‐Amersdorfer et al. · Proceedings of the National Academy of Sciences · 1998 · 989 citations · Full text

, , +14

Molecular diversity of heparan sulfate

Jeffrey D. Esko, Ulf Lindahl · Journal of Clinical Investigation · 2001 · 819 citations

, , +18